Genetic variation in nitric oxide synthase 2A (NOS2A) and risk for multiple sclerosis
نویسندگان
چکیده
منابع مشابه
Investigation of an inducible nitric oxide synthase gene (NOS2A) polymorphism in a multiple sclerosis population.
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) affecting most commonly the Caucasian population. Nitric oxide (NO) is a biological signaling and effector molecule and is especially important during inflammation. Inducible nitric oxide synthase (iNOS) is one of the three enzymes responsible for generating NO. It has been reported that there is an ex...
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Nitric oxide (NO) is a free radical signaling molecule with remarkably complex biochemistry. Its involvement in multiple sclerosis (MS) had been postulated soon after the discovery of the critical role NO plays in inflammation. However, the extent of NO's contribution to MS is not yet understood, party due to the often opposing roles that NO can play in cellular processes. This review briefly c...
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Asbestos, a known occupational pollutant, may upregulate the activity of inducible nitric oxide synthase (iNOS) and thus the production of nitric oxide (NO). This study investigated whether iNOS (CCTTT)(n) polymorphism is associated with an increased asbestosis risk in exposed workers. The study cohort consisted of 262 cases with asbestosis and 265 controls with no asbestos-related disease. For...
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ژورنال
عنوان ژورنال: Genes & Immunity
سال: 2008
ISSN: 1466-4879,1476-5470
DOI: 10.1038/gene.2008.41